Fluorinated Aromatic Amino Acids and its Therapeutic Applications

Fluorination became the more radical approach for modification of leading compounds in medicinal chemistry [1,2]. Due to its small size and high electronegativity, fluorine forms a strong covalent bond with carbon, shows a significant impact on neighboring groups that alter the stability and reactivity of the molecules, helps to creates more stable protein folds [3,4]. Fluorinated amino acids were synthesized a long time back and showed significant physiological activity [5]. Nevertheless, some of these analogues have more applications than others due to their availability, biological activity and role in protein structure and functions. Several newly synthesized analogues over the past decade have not yet been pursued far enough to study their biological activities (Table 1).